
Involving random and sequential crossover of clustered groups

Randomized Controlled Trial
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http://www.implementationscience.com/content/4/1/50
FRAMEWORK
RCT's aim to determine whether a cause-effect relation exists between treatment and outcome, and are also used in assessing the cost effectiveness of a treatment. They are characterized by study group randomization and "double blind" design features.
Studies that involve multiple levels of random assignment or allocation are often useful in increasing the precision of inferences.
Description (currently blank).
Wandersman A, Duffy J, Flaspohler P, Noonan R, Lubell K, et al. Bridging the gap between prevention research and practice: the interactive systems framework for dissemination and implementation. American Journal of Community Psychology 2008, 41(3–4), 171-181.
Flaspohler P, Lesesne CA, Puddy RW, Smith E, Wandersman A. Advances in bridging research and practice: introduction to the second special issue on the interactive system framework for dissemination and implementation American Journal of Community Psychology 2012, 50(3-4), 271-281.
http://www.cdc.gov/ViolencePrevention/isf.html
This is a research study design that is increasingly being used in the evaluation of service delivery type interventions. The design involves random and sequential crossover of clusters from control to intervention until all clusters are exposed.
More clusters are exposed to the intervention towards the end of the study than in its early stages, so sample size calculations and analysis must make allowance for both the clustered nature of the design and the confounding effect of time.

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http://www.bmj.com/content/350/bmj.h391
The stepped wedge design is an alternative to traditional parallel cluster studies, in which the intervention is delivered in only half the clusters with the remainder functioning as controls. When the clusters are relatively homogeneous (that is, the intra-cluster correlation is small), parallel studies tend to deliver better statistical performance than a stepped wedge trial. However, if substantial cluster-level effects are present (that is, larger intra-cluster correlations) or the clusters are large, the stepped wedge design will be more powerful than a parallel design, even one in which the intervention is preceded by a period of baseline control observations.
"Hybrid (mixed method) designs focus on collecting, analyzing and merging both quantitative and qualitative data into one or more studies.
The Central Premise of these designs is that the use of quantitative and qualitative approaches in combination provides a better understanding of research issues than either approach alone. "
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http://www.implementationscience.com/content/4/1/50
FRAMEWORK
Pragmatic Trials allow us to evaluate interventions under typical conditions, with typical patients vs. under ideal conditions with a homogeneous set of selected patients (Explanatory Trials).
Traditional trials usually take a long time to translate into practice; it takes an average of 17 years for just 14% of research to translate into practice.
The conditions under which traditional trials are conducted are often not seen by practitioners as relevant to their practice or patient populations.
Although there are over 18,000 randomized controlled trials (RCT's) published each year, the vast majority of systematic reviews conclude that there is not enough evidence to inform clinical decisions.

Description (currently blank).
Wandersman A, Duffy J, Flaspohler P, Noonan R, Lubell K, et al. Bridging the gap between prevention research and practice: the interactive systems framework for dissemination and implementation. American Journal of Community Psychology 2008, 41(3–4), 171-181.
Flaspohler P, Lesesne CA, Puddy RW, Smith E, Wandersman A. Advances in bridging research and practice: introduction to the second special issue on the interactive system framework for dissemination and implementation American Journal of Community Psychology 2012, 50(3-4), 271-281.
http://www.cdc.gov/ViolencePrevention/isf.html
No study is completely pragmatic, nor is it completely explanatory. Rather, each study is somewhere along the continuum, having characteristics and degrees of each study type.
The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) was developed by Thorpe and colleagues to measure where a given study might fall. It can be applied to illustrate the degree to which a trial is pragmatic or explanatory. It used ten domains plotted on a “spoke-and-wheel” diagram. Since then, it has been revised to feature 9 domains related to pragmatic trials.
To Learn more about PRECIS-2 and use our interactive PRECIS-2 Wheel;
See our e-book on Pragmatic Trials
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http://www.bmj.com/content/350/bmj.h2147
Original (PRECIS) Source: Journal of Clinical Epidemiology, Vol 62, Thorpe, KE et al., A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers, Pages 464-475, Copyright (2009), with permission from Elsevier.
FRAMEWORK
Need some text for this - References, etc.?
Description (currently blank).
Wandersman A, Duffy J, Flaspohler P, Noonan R, Lubell K, et al. Bridging the gap between prevention research and practice: the interactive systems framework for dissemination and implementation. American Journal of Community Psychology 2008, 41(3–4), 171-181.
Flaspohler P, Lesesne CA, Puddy RW, Smith E, Wandersman A. Advances in bridging research and practice: introduction to the second special issue on the interactive system framework for dissemination and implementation American Journal of Community Psychology 2012, 50(3-4), 271-281.
http://www.cdc.gov/ViolencePrevention/isf.html
- To be dissolved into other sections
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